Streptozotocin : Uses, Mechanism of Action & Side Effects
Book Details
Format
Hardback or Cased Book
ISBN-10
1631172557
ISBN-13
9781631172557
Publisher
Nova Science Publishers Inc
Imprint
Nova Science Publishers Inc
Country of Manufacture
US
Country of Publication
GB
Publication Date
May 22nd, 2014
Print length
170 Pages
Weight
470 grams
Dimensions
26.30 x 18.10 x 1.40 cms
Product Classification:
Oncology
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Streptozotocin (STZ), an antibiotic and anticancer agent, is the most prominent diabetogenic chemical agent in diabetes research due to its cytotoxicity in pancreatic beta-cells. The selective toxicity of STZ to beta cells occurs because of its preferential accumulation in beta cells through uptake via GLUT2 glucose transporter. Insulin dependent diabetes mellitus can be induced by either single high dose or multiple low-dose STZ injections. At low dose, STZ induces pancreatic beta-cell apoptosis and at high dose it causes necrosis. Though STZ itself can cause carcinogenesis and renal, hepatic and muscle myoblast toxicity, these side effects can be minimised or completely avoided by using lower doses. This book discusses in further detail the different ways in which streptozotocin is used in the medical field.
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