Modulation of Cardiac Calcium Sensitivity

The calcium sensitizers are a new class of drugs which increase the force of contraction of the heart. These drugs offer an alternative approach to the treatment of heart failure. This study describes the physiological, biochemical and clinical background to this novel mechanism of action.

The devlopment of calcium sensitizers represents the first major innovation in the treatment of heart failure for over 200 years. Unlike other drugs in this area, they do not increase the intracellular calcium concentration and do not have the side effects associated with that mechanism of action. These drugs offer an exciting alternative approach to the treatment of heart failure, and this volume provides an authoritative overview of the physiology, biochemistry, and clinical issues involved. It will be of particular interest to all those concerned with the treatment of heart failure.

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