Chitosan : Modifications & Applications in Dosage Form Design

by Ashok Kumar Tiwary , Bharti Sapra , Gurpreet Kaur , Vikas Rana

Book Details

Format Paperback / Softback

ISBN-10 1617611743

ISBN-13 9781617611742

Publisher Nova Science Publishers Inc

Imprint Nova Science Publishers Inc

Country of Manufacture US

Country of Publication GB

Publication Date Feb 24th, 2012

Print length 110 Pages

Weight 182 grams

Dimensions 22.90 x 15.90 x 0.70 cms

Product Classification: Pharmacy / dispensing

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Chitosan is the deacetylated form of chitin. Generally, the substance becomes soluble in dilute acids when the degree of deacetylation is more than 50%. The solubility of chitosan in dilute acids is often needed to be modified when specific drug release properties have to be tailored into the dosage form. The available toxicological data on chitosan and its modified forms appears to indicate its safety for oral use because high doses have been found to be tolerated well in rodents and rabbits. However, its local action as a haemostatic together with its ability to activate macrophages and cause cytokine release may require a careful assessment of its safety for parenteral use. This book offers the dynamics of chitosan''s detailed composition.

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