Biology of Vascular Smooth Muscle

This book provides a concise yet comprehensive review of the morphological, biochemical, electrical, mechanical, and metabolic properties of vascular smooth muscle, the regulation of vascular activities and the intracellular signaling involved.

Architecture of the vessel wall.- Ultrastructure of vascular smooth muscle.- Vascular endothelium.- Electrical and mechanical properties of vascular smooth muscle.- Biochemistry of the contractile proteins of smooth muscle.- Metabolism of vascular smooth muscle.- Neurotransmitters.- Endothelium-derived factors.- Local metabolic factors.- Shear stress, myogenic response, and blood flow autoregulation.- Intracellular Ca2+ regulation.- Regulation of myosin light chain phosphorylation.- Cyclic AMP signaling.- Cyclic GMP signaling.- MicroRNAs and vasoreactivity.- Extracellular vesicles as unique signaling messengers.- Genetic and epigenetic modification.- Coronary vasoreactivity.- Cerebral vasoreactivity.- Pulmonary vasoreactivity.- Renal vasoreactivity.- Hypoxic vasoreactivity .- Ageing and vasoreactivity.

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