Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research

Softcover reprint of the original 1st ed. 1994

Book Details

Format Paperback / Softback

Book Series Ernst Schering Foundation Symposium Proceedings

ISBN-10 3662030217

ISBN-13 9783662030219

Edition Softcover reprint of the original 1st ed. 1994

Publisher Springer-Verlag Berlin and Heidelberg GmbH & Co. KG

Imprint Springer-Verlag Berlin and Heidelberg GmbH & Co. K

Country of Manufacture DE

Country of Publication GB

Publication Date Nov 23rd, 2012

Print length 227 Pages

Product Classification: Pharmacology Biochemistry

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Metabolic research and especially that which focuses on the monooxygenase cytochrome P450 system has gone through dramatic progressive changes within the last decade. Availability of highly sophisticated analytical techniques has contributed to increased molecular understanding of biotransformation pathways. Nowadays designer drugs are computer composable focussing on metabolic stability. The rapid development of recombinant enzymes has, in many cases, replaced the intensive work on P450 isolation from naturally occurring sources. Recombinant P450s can be expressed in cell lines and thus made available for reproducible and constant use addressig a large number of scientific questions. This book describes the present position of such research.

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